This Thursday at noon EST, before he commences Berkshire Hathaway’s annual meeting weekend, the billionaire investor will sit down for his first-ever interview that incorporates social media.

The topic is new for him too: “Warren Buffett on Women and Work…and other Wisdom.”

The billionaire investor is doing the Fortune live video chat to promote “Warren Buffett is Bullish on…Women,” his essay that will be published online this Thursday morning and in the 2013 Fortune 500 issue May 6.

Buffett is no stranger to women — he’s an honorary guest and interview subject each year at Fortune‘s Most Powerful Women Summit. But he had never written about women. He feels motivated now, he says, by the buzz around women and work – thanks to Facebook COO Sheryl Sandberg’s Lean In and Yahoo CEO Marissa Mayer’s HR policies.

Going social, Buffett will answer not only Fortune’s questions but questions via Twitter too — on three topics:

–    women and the economy
–    women and management
–    women and investing

You can send your questions via this Twitter hashtag: #FortuneBuffett.

Buffett will talk with me — and an audience of students and VIPs — at the University of Nebraska Omaha this Thursday at noon EST. Watch the chat live on CNNMoney.com.