That’s because, when it comes to filling out a March Madness bracket, there are a lot of behavioral biases at play. We all suffer from illusions of control, overreliance on experts, and something called affect heuristic, which pushes us to underestimate the risks of choices we like (for example, by playing down the pitfalls of choosing Temple because you’re from Philly).

While it can’t tell us whether to choose Kansas over North Carolina or if Gonzaga will make a run, behavioral economics—which studies the effects of psychological, social, cognitive, and emotional factors on decisions and their consequences—at least offers a process for analyzing how and why people make decisions (like, say, bracket picks) and suggests ways to avoid common mistakes.

These same behavioral biases come into play in entrepreneurship. That’s why, when sport commentators make March Madness picks, they often use metaphors related to the business world. They talk about ups and downs in a team’s stock, recent performance “streaks,” and confidence in company (team) leadership.

So now let’s take a moment to look at how understanding behavioral economics can be essential in helping entrepreneurs become better business leaders—and March Madness pickers.

Entrepreneurs are humans

Of course, we all fall short of the idealized, fully rational “Econs” who populate traditional economic textbooks. Indeed, most of our decisions are driven by logically questionable narratives and mental heuristics that are better suited to dealing with risks in the savannah than in the C-suite or college basketball bracket.

These predictable human foibles are especially hazardous for entrepreneurs operating in a world where eight out of 10 businesses fail within the first 18 months. Research shows that those placing bets often fall victim to a sense of overconfidence. In one experiment conducted at a racetrack, gamblers were asked how confident they were in their bets either immediately before or after placing their bets; those polled afterward were significantly more confident in their choice than those asked beforehand. No wonder entrepreneurs and March Madness players are so optimistic about their chances of succeeding.

Another impediment to our ability to clearly assess risks is the so-called egocentric bias: We tend to believe that our preferences and opinions are representative of the general population—“If I like Duke, many others must too”—even when they aren’t.

Compounding the problem, poorly structured teams can amplify such cognitive biases into the kind of groupthink that bedevils corporate cultures. For example, studies conducted by legal scholar Cass Sunstein reveal that a risk-seeking individual deliberating on a business decision will be even more willing to engage in risky behavior after talking with like-minded people—even when contradictory information is available.

The good news for entrepreneurs—and bracket pickers—is that data science and well-structured teams can help us “think slower” and ameliorate such cognitive biases. Analyzing historical data can help us recognize narrative fallacies and overconfident forecasts; input from a diversity of opinions can help overcome egocentric biases. And smart teams with self-silencing leaders, devil’s advocates, clever opinion-aggregation mechanisms, and members with good social perception tend to take risks that are smart and calculated rather than foolish and intuitive.

Customers are humans

In their book Nudge, Sunstein and behavioral economist Richard Thaler introduced the idea of “choice architecture”—small changes in the way options are presented that can have disproportionate impacts on the choices we make. This idea is taking the public-policy world by storm (President Obama signed an executive order for a White House “nudge unit” last September), and the private sector is beginning to tap into the power of choice architecture as well.

True, the idea of choice architecture, particularly when implemented by a government agency, can seem like a creepy form of social engineering. But choice architecture’s actual point is to help consumers more easily get to the choice that best serves them. Think of it this way: The mark of a well-designed computer or electronic gadget is that it can be immediately used without an instruction manual; its design is people-centric. Similarly, why not design choice environments for financial products or food choices to nudge our short-term selves toward the smart choices that our long-term selves would prefer?

There is a wide-open space for socially minded entrepreneurs to innovate product and service designs that go with, rather than against, the grain of human psychology. For example, even after years of research into choice overload, retailers still commonly present customers with too many choices—for instance, offering 20 flavors of jam instead of five— which often leads to disengagement. This is all the truer when firms offer customers large menus of financial products, which, unlike arrays of jam flavors, require expert guidance, especially considering the long-term stakes.

In these situations, a choice-architecture option is to offer customers smaller, more personalized menus. This type of collaborative filtering is commonly used to help us choose books and movies—why not healthy foods and winning teams as well? Another choice-architecture mechanism is the smart default, which has a proven track record in complex areas such as personal finance and health. Perhaps your 401(k) deferral, when you initially signed up, suggested a default amount for automatic enrollment. Or in the NCAA tournament, a bracket could come pre-filled with higher seeds winning all games, forcing the pool player to actively choose underdogs.

Another major theme of behavioral economics is that even the most disciplined executive procrastinates and struggles with limited self-control. Sure, our future selves want to be svelte and wealthy, but at any given moment our present selves is happy to put off the visit to the gym or financial adviser. Commitment devices provide a tangible way beyond this familiar impasse: For example, Jim signs a contract agreeing to donate money to a charity—most effectively, one for a cause that he loathes—in the event that he fails to stick to a commitment (a certain number of gym visits in the next month, for example). StickK and BeeMinder are two companies that have run with this idea.

And don’t underestimate the power of peer comparisons to influence behavior. HelloWallet institutes both personal and peer tracking to persuade consumers to better invest for the future. In the same vein, Opower uses social proof to motivate households to decrease energy usage with timely messages such as, “You used 70% less than your efficient neighbors.”

There is tremendous excitement about the disruptive power of big data and the Internet of Things, and yet an equally powerful engine of innovation lies in understanding how our minds work. Increasingly, entrepreneurs will look to behavioral economics as a source of the people-centric thinking needed to help create new generations of products and services.

Plus, it could help you make smarter choices on your March Madness bracket.

Jim Guszcza is the U.S. chief data scientist for Deloitte Consulting LLP.