First, the Republican National Convention is heating up in the battleground state of Ohio. Fortune‘s Brian O’Keefe and Shawn Tully join us to discuss the media frenzy, the facts, and the fallout. Plus, senior editor Dan Primack comes to us live via Skype from the Ohio convention center to offer his own analysis. And, the Fortune 2016 Global 500 list is out! We’ll discuss the economic forces that reshaped this year’s list.

Next, Jes Staley, CEO of Barclays (BCS), and his brother, Peter Staley, HIV/AIDS and LGBT rights activist, tell Patricia Sellers why Peter quit his job on Wall Street in the late ‘80s, and how his dramatic actions on the New York Stock Exchange floor prompted one drug company to drop the price of a vital medication.

Then, we have more highlights from last week’s Fortune Brainstorm Tech conference. OpenTable CEO Christa Quarles tells Fortune’s Aaron Task about the company’s latest innovations and plans for growth. And Bill Maris, CEO of GV, and Christine Aylward, managing director of Foresite Capital, discuss companies that are revolutionizing the future of cancer diagnoses and treatment.

Former Twitter (TWTR) exec Katie Jacobs Stanton stops by to talk with Fortune‘s Jennifer Reingold about her new role as CMO of Color Genomics, a startup that identifies your risk of a cancer with a simple test.

And Anne closes the show by sharing some of her favorite stories from the newest issue of Fortune.