The attack, threatened for weeks by Israel, comes as the Middle East sits on the precipice of a regional war more than a year after an initial attack by the militant group Hamas on Israel. In the time since, Israel has launched a devastating ground offensive in the Gaza Strip and an invasion of neighboring Lebanon, targeting militants long armed and aided by Tehran.

Israel’s military described the attack Saturday as “precise strikes on military targets in Iran,” without immediately elaborating.

“The regime in Iran and its proxies in the region have been relentlessly attacking Israel since Oct. 7 … including direct attacks from Iranian soil,” Israeli military spokesman Rear Adm. Daniel Hagari said in a prerecorded video statement. “Like every other sovereign country in the world, the State of Israel has the right and the duty to respond.”

In Tehran, the Iranian capital, the sound of explosions could be heard, with state-run media there initially acknowledging the blasts and saying some of the sounds came from air defense systems around the city.

A Tehran resident told The Associated Press that at least seven explosions could be heard, which rattled the surrounding area. The resident spoke on condition of anonymity for fear of reprisals.

International flights began diverting around western Iran as news of the strikes broke, flight-tracking data showed.

Meanwhile, state media in Syria described its air defenses as targeting “hostile targets” there as well.

Iran has launched two ballistic missile attacks on Israel in recent months amid the ongoing Israel-Hamas war in the Gaza Strip that began with the Hamas attack on Israel on Oct. 7, 2023. That initial attack killed some 1,200 people and saw 250 others taken hostage back to the seaside enclave.

In the time since, more than 42,000 Palestinians have been killed in Gaza, according to local health officials who don’t delineate between civilians and combatants. The U.N. has said hundreds of thousands of people have been trapped with little food or supplies as Israeli forces close in on the northern Gaza town of Jabaliya, while food and other aid remains scarce in the enclave. Israeli military operations in the West Bank in the time since have killed hundreds more.

Israel also has launched a ground invasion of Lebanon and a series of punishing airstrikes that have rattled that country.

The strike Saturday happened just as U.S. Secretary of State Antony Blinken was arriving back in the U.S. after a tour of the Middle East where he and other U.S. officials had warned Israel to tender a response that would not further escalate the conflict in the region and exclude nuclear sites in Iran.

White House National Security Council spokesman Sean Savett said in a statement that “we understand that Israel is conducting targeted strikes against military targets in Iran” and referred reporters to the Israeli government for more details on their operation.

Two U.S. officials said the U.S. was notified by Israel in advance of the strikes. They said there was no U.S. involvement in the operation. The officials spoke on condition of anonymity to discuss an ongoing operation.

Israel had vowed to hit Iran hard following a massive Iranian missile barrage on Oct. 1. Iran said its barrage was in response to deadly Israeli attacks against its proxy in Lebanon, Hezbollah, and it has promised to respond to any retaliatory strikes.

Israel and Iran have been bitter foes since the 1979 Islamic Revolution. Israel considers Iran to be its greatest threat, citing its leaders’ calls for Israel’s destruction, their support for anti-Israel militant groups and the country’s nuclear program.

Israel and Iran have been locked in a yearslong shadow war. A suspected Israeli assassination campaign has killed top Iranian nuclear scientists. Iranian nuclear installations have been hacked or sabotaged, all in mysterious attacks blamed on Israel. Meanwhile, Iran has been blamed for a series of attacks on shipping in the Middle East in recent years, which later grew into the attacks by Yemen’s Houthi rebels on shipping through the Red Sea corridor.

But since Hamas’ Oct. 7 attack, the battle has increasingly moved into the open. Israel has recently turned its attention to Hezbollah, which has been firing rockets into Israel since the war in Gaza began. Throughout the year, a number of top Iranian military figures have been killed in Israeli strikes in Syria and Lebanon.

Iran fired a wave of missiles and drones at Israel last April after two Iranian generals were killed in an apparent Israeli airstrike in Syria on an Iranian diplomatic post. The missiles and drones caused minimum damage, and Israel — under pressure from Western countries to show restraint — responded with a limited strike.

But after Iran’s early October missile strike, Israel promised a tougher response.

Meanwhile Friday, Israeli strikes on residential areas in southern Gaza killed 38 people, including 13 children from the same extended family, Palestinian health officials said.

In northern Gaza, health officials reported that Israeli forces had raided Kamal Adwan Hospital, one of the few medical facilities still functioning in the area. Israel has renewed its offensive against Hamas in the north in recent weeks, and aid groups are sounding the alarm over dire humanitarian conditions.

In Lebanon, Israeli strikes on the country’s southeast killed three journalists working for news outlets that are considered to be aligned with Hezbollah.

___

Associated Press writers Amir Vahdat in Tehran, Iran, and Lolita C. Baldor, Farnoush Amiri and Zeke Miller in Washington contributed to this report.