• Home
  • Latest
  • Fortune 500
  • Finance
  • Tech
  • Leadership
  • Lifestyle
  • Rankings
  • Multimedia

Trendingnow

1

As Big Tech showers employees with perks to win the talent war, Nvidia built a nearly $5 trillion company by making people pay for their own lunch

2

MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year

3

Current price of oil as of July 1, 2026

1

As Big Tech showers employees with perks to win the talent war, Nvidia built a nearly $5 trillion company by making people pay for their own lunch

2

MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year

3

Current price of oil as of July 1, 2026
Alzheimer's

Those most at risk of developing Alzheimer’s may lose this sense before cognitive decline sets in, new research suggests

By
Erin Prater
Erin Prater
Down Arrow Button Icon
By
Erin Prater
Erin Prater
Down Arrow Button Icon
July 26, 2023, 4:15 PM ET
Those who carry a gene variant associated with the strongest risk of Alzheimer’s disease may lose their ability to detect smells before they begin to lose cognitive function, according to a new study published Wednesday in the journal Neurology.
Those who carry a gene variant associated with the strongest risk of Alzheimer’s disease may lose their ability to detect smells before they begin to lose cognitive function, according to a new study published Wednesday in the journal Neurology.Getty Images
Add Fortune on Google for similar content.

Those who carry a gene variant associated with the strongest risk of Alzheimer’s disease may lose their ability to detect smells before they begin to lose cognitive function—a potential sign of more severe disease to come.

That’s according to a new study published Wednesday in the journal Neurology, by researchers at the University of Chicago.

Researchers followed more than 1,000 older U.S. adults for 10 years, testing their genes, as well as their ability to smell and think at various intervals. Those who carry the APOE e4 gene variant—which has the strongest known association with developing the disease—began to struggle to detect smells between ages 65-69, a decade before those without the mutation. Both cognition and the ability to identify odors later declined more rapidly in carriers than non-carriers.

Those with the variant were nearly 40% less likely to have good odor detection at any given point in the study than those without the variant.

Given the results, “testing odor sensitivity may be useful to predict future impaired cognitive function,” the authors wrote.

The study used data collected from the National Social Life Health and Aging 

Project, which did not track whether participants eventually developed Alzheimer’s, Dr. Matthew GoodSmith, an internist at the University of Chicago and lead author on the study, told Fortune.

Still, the results “definitely suggest testing sense of smell as a potential diagnostic tool, or maybe as part of a battery of tools used to assess someone’s risk of developing full-blown Alzheimer’s disease,” he said.

“It gives us a little bit of information about the interplay between smell and loss of cognition, and we hope it will spur further research into this.”

Signs of Alzheimer’s disease

Alzheimer’s disease, a neurodegenerative condition, is the most common type of dementia. It begins with mild memory loss and may eventually progress to the inability to carry a conversation or respond to the environment, according to the U.S. Centers for Disease Control and Prevention.

Those who are concerned they or a loved one might have Alzheimer’s or another form of dementia should talk to their doctor, who may recommend they see another specialist, like a neuropsychologist or a neurologist.

Warning signs of the condition, according to the AARP, include:

  • Difficulty performing daily tasks like keeping track of bills and following a recipe while cooking
  • Repetition, such as asking the same question over and over and telling the same story multiple times
  • Struggling to find the right word
  • Getting lost
  • Personality changes, such as becoming more anxious, confused, afraid, or paranoid
  • Confusion about time and place, especially if someone can’t remember where they are or how they got there
  • Misplacing items in unusual areas
  • Trouble with hygiene
  • Trouble with handling money
  • Sudden loss of things one is usually interested in, including family, friends, work, and social events
  • Forgetting old memories

GoodSmith might add changes in sense of smell to the list. While there are many reasons someone might lose their sense of smell, the symptom “might increase a primary care doctor’s index of suspicion” and lead them to investigate Alzheimer’s in a patient with other potential signs, he said.

There’s currently no cure for Alzheimer’s, though treatment can alter the progression of the disease. Ever an optimist, GoodSmith said he feels as if “it’s only a matter of time before there are interventions to slow cognitive decline.”

If and when there are, being able to detect the condition as early as possible will be key—perhaps through a simple, noninvasive test like that of the sense of smell, he said.

“It might be a useful thing once we develop more active therapeutics.”

About the Author
By Erin Prater
See full bioRight Arrow Button Icon
Add Fortune on Google for similar content.

Latest in

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025

Most Popular

Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Finance
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam
By Fortune Editors
October 20, 2025
Fortune Secondary Logo
Rankings
  • 100 Best Companies
  • Fortune 500
  • Global 500
  • Fortune 500 Europe
  • Most Powerful Women
  • World's Most Admired Companies
  • See All Rankings
  • Lists Calendar
Sections
  • Finance
  • Fortune Crypto
  • Features
  • Leadership
  • Health
  • Commentary
  • Success
  • Retail
  • Mpw
  • Tech
  • Lifestyle
  • CEO Initiative
  • Asia
  • Politics
  • Conferences
  • Europe
  • Newsletters
  • Personal Finance
  • Environment
  • Magazine
  • Education
Customer Support
  • Frequently Asked Questions
  • Customer Service Portal
  • Privacy Policy
  • Terms Of Use
  • Single Issues For Purchase
  • International Print
Commercial Services
  • Advertising
  • Fortune Brand Studio
  • Fortune Analytics
  • Fortune Conferences
  • Business Development
  • Group Subscriptions
About Us
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • About Us
  • Press Center
  • Work At Fortune
  • Terms And Conditions
  • Site Map
  • Facebook icon
  • Twitter icon
  • LinkedIn icon
  • Instagram icon
  • Pinterest icon

Latest in

U.S. Treasury Secretary Scott Bessent
EconomyDebt
AI’s $2.2 trillion deficit fix is already half fake, economists say
By Tristan BoveJuly 2, 2026
35 minutes ago
s
Personal FinanceSports
The sports economy is unaffordable at the bar, let alone the stadium
By Catherina GioinoJuly 2, 2026
38 minutes ago
m
Politicsfraud
Trump fights fraud by freezing funding for New York’s Medicaid Fraud Control Unit
By Ali Swenson, Geoff Mulvihill and The Associated PressJuly 2, 2026
39 minutes ago
Anthropic CEO Dario Amodei
AIEye on AI
Anthropic’s Fable model is back. But U.S. AI policy is still a mess
By Jeremy KahnJuly 2, 2026
44 minutes ago
sb
North AmericaU.S. Department of the Treasury
Scott Bessent goes after the top Mexican cartel’s new billion-dollar business: gas stations
By Fatima Hussein and The Associated PressJuly 2, 2026
45 minutes ago
t
PoliticsWhite House
Trump trots out the C-word — communism — not getting the memo that capitalism has been largely discredited with Gen Z
By Steven Sloan and The Associated PressJuly 2, 2026
1 hour ago

Most Popular

As Big Tech showers employees with perks to win the talent war, Nvidia built a nearly $5 trillion company by making people pay for their own lunch
Big Tech
As Big Tech showers employees with perks to win the talent war, Nvidia built a nearly $5 trillion company by making people pay for their own lunch
By Marco Quiroz-GutierrezJuly 1, 2026
2 days ago
MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year
Success
MacKenzie Scott alone accounted for one-third of America's $19.2 billion in megagifts last year
By Sydney LakeJune 25, 2026
8 days ago
Current price of oil as of July 1, 2026
Personal Finance
Current price of oil as of July 1, 2026
By Joseph HostetlerJuly 1, 2026
1 day ago
Trump got a $78K pension from the Screen Actors Guild in 2025 because he appeared in Home Alone 2 in 1992
Politics
Trump got a $78K pension from the Screen Actors Guild in 2025 because he appeared in Home Alone 2 in 1992
By Sasha RogelbergJuly 1, 2026
1 day ago
CEO of $248 billion cybersecurity company says workers are about to face a ‘Darwinian moment’ thanks to AI: Evolve or get cut
Success
CEO of $248 billion cybersecurity company says workers are about to face a ‘Darwinian moment’ thanks to AI: Evolve or get cut
By Emma BurleighJuly 1, 2026
1 day ago
Philanthropy leader at Warren Buffett and Bill Gates’ Giving Pledge says children of billionaires are pushing them to give their wealth away faster
Success
Philanthropy leader at Warren Buffett and Bill Gates’ Giving Pledge says children of billionaires are pushing them to give their wealth away faster
By Preston ForeJune 27, 2026
5 days ago

© 2026 Fortune Media IP Limited. All Rights Reserved. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy | CA Notice at Collection and Privacy Notice | Do Not Sell/Share My Personal Information
FORTUNE is a trademark of Fortune Media IP Limited, registered in the U.S. and other countries. FORTUNE may receive compensation for some links to products and services on this website. Offers may be subject to change without notice.