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An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

An hour in the Oval Office with President Trump Fortune Editor-in-Chief: Alyson Shontell sat down with President Trump in the Oval Office for an hour. Tariffs, Intel, AI, Boeing, Iran—and the question every CEO eventually has to answer: who's next?

HealthAlzheimer's

Drugs like Ozempic and Wegovy are linked to a lower risk of Alzheimer’s disease, new study says

By
Ani Freedman
Ani Freedman
Fellow, Fortune Well
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By
Ani Freedman
Ani Freedman
Fellow, Fortune Well
Down Arrow Button Icon
October 24, 2024, 12:31 PM ET
The active ingredient in drugs like Ozempic and Wegovy could lower the risk of developing Alzheimer’s disease, according to a new study.
The active ingredient in drugs like Ozempic and Wegovy could lower the risk of developing Alzheimer’s disease, according to a new study.Getty Images

Semaglutide—the diabetes and weight-loss drug known by brand names like Ozempic and Wegovy—is continuing to show its potential to treat a wide range of other conditions.

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While recent studies have revealed that these drugs may help stop opioid addiction, smoking, and even help people live longer, a new study published in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association now also links semaglutide to a decreased risk of Alzheimer’s disease.

In the study, researchers at Case Western Reserve School of Medicine analyzed three years of electronic records of nearly one million Americans with type 2 diabetes. They compared patients prescribed semaglutide—a glucagon-like peptide-1 (GLP-1) receptor agonist—to those prescribed one of seven other anti-diabetic drugs, including metformin, dipeptidyl-peptidase-4 inhibitors (DPP-4i), and other GLP-1RAs (which mimic the effects of GLP-1s). Patients prescribed semaglutide had a 40% to 70% reduced risk of first-time Alzheimer’s diagnosis, compared to other antidiabetic medications.

“The result is what we expected,” Rong Xu, biomedical informatics professor at Case Western Reserve University and lead researcher on the study, tells Fortune. 

Given other studies that show semaglutide can help reduce inflammation in the body, prevent neuron damage, promote weight loss, control diabetes, and prevent cardiovascular disease—in addition to helping curb the urge to smoke and drink—Xu says the drug is already lowering risk factors for Alzheimer’s.

“If we can target these risk factors…semaglutide can be beneficial in preventing or slowing down Alzheimer’s disease symptoms or development,” Xu says.

Xu makes it clear that this study wasn’t meant to examine whether semaglutide lowers the risk for Alzheimer’s in people without diabetes.

“Diabetes itself is a risk factor [for Alzheimer’s],” she says. Because of that, Xu and her team wanted to see if people at heightened risk—those who have diabetes—would have better outcomes with semaglutide versus other diabetes medications.

Researchers can’t say that semaglutide does lower Alzheimer’s risk, only that there is a link. More research is needed.

But Xu is also optimistic for what these study findings might mean for people currently diagnosed with Alzheimer’s. She’d like to see if semaglutide could improve outcomes or have a therapeutic effect on those currently managing Alzheimer’s symptoms.

For more on Alzheimer’s:

  • Why Barbara Corcoran of ‘Shark Tank’ ‘should’ve seen a psychologist’ while caring for mom with Alzheimer’s
  • These 5 lifestyle changes improved brain function for those with early Alzheimer’s
  • Belly fat tied to brain health in middle-aged adults at high risk of Alzheimer’s, study finds—but it’s worse for men

Subscribe to Well Adjusted, our newsletter full of simple strategies to work smarter and live better, from the Fortune Well team. Sign up for free today.

About the Author
By Ani FreedmanFellow, Fortune Well
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Ani Freedman is a fellow on the Fortune Well team.

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